CovidSeniorV1, Main, Exploration, bibRecord, 000194

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.

Identifieur interne : 000194 ( Main/Exploration ); précédent : 000193; suivant : 000195

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.

Auteurs : Rob J. Hallifax [Royaume-Uni] ; Benedict Ml Porter [Royaume-Uni] ; Patrick Jd Elder [Royaume-Uni] ; Sarah B. Evans [Royaume-Uni] ; Chris D. Turnbull [Royaume-Uni] ; Gareth Hynes [Royaume-Uni] ; Rachel Lardner [Royaume-Uni] ; Kirsty Archer [Royaume-Uni] ; Henry V. Bettinson [Royaume-Uni] ; Annabel H. Nickol [Royaume-Uni] ; William G. Flight [Royaume-Uni] ; Stephen J. Chapman [Royaume-Uni] ; Maxine Hardinge [Royaume-Uni] ; Rachel K. Hoyles [Royaume-Uni] ; Peter Saunders [Royaume-Uni] ; Anny Sykes [Royaume-Uni] ; John M. Wrightson [Royaume-Uni] ; Alastair Moore [Royaume-Uni] ; Ling-Pei Ho [Royaume-Uni] ; Emily Fraser [Royaume-Uni] ; Ian D. Pavord [Royaume-Uni] ; Nicholas P. Talbot [Royaume-Uni] ; Mona Bafadhel [Royaume-Uni] ; Nayia Petousi [Royaume-Uni] ; Najib M. Rahman [Royaume-Uni]

Source :

BMJ open respiratory research [ 2052-4439 ] ; 2020.

RBID : pubmed:32928787

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Décubitus ventral (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Mâle (MeSH), Odds ratio (MeSH), Oxygénothérapie (méthodes), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Positionnement du patient (méthodes), Royaume-Uni (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Ventilation en pression positive continue (méthodes), Ventilation non effractive (méthodes), Vigilance (MeSH), Études rétrospectives (MeSH), Évolution de la maladie (MeSH).
MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- méthodes : Oxygénothérapie, Positionnement du patient, Ventilation en pression positive continue, Ventilation non effractive.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Décubitus ventral, Femelle, Humains, Mâle, Odds ratio, Pandémies, Royaume-Uni, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Vigilance, Études rétrospectives, Évolution de la maladie.
Wicri :
- geographic : Royaume-Uni.

English descriptors

KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Continuous Positive Airway Pressure (methods), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Disease Progression (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Noninvasive Ventilation (methods), Odds Ratio (MeSH), Oxygen Inhalation Therapy (methods), Pandemics (MeSH), Patient Positioning (methods), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Prone Position (MeSH), Retrospective Studies (MeSH), Treatment Outcome (MeSH), United Kingdom (MeSH), Wakefulness (MeSH).
MESH :
- geographic : United Kingdom.
- methods : Continuous Positive Airway Pressure, Noninvasive Ventilation, Oxygen Inhalation Therapy, Patient Positioning.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Aged, 80 and over, Betacoronavirus, Disease Progression, Female, Humans, Male, Middle Aged, Odds Ratio, Pandemics, Prone Position, Retrospective Studies, Treatment Outcome, Wakefulness.

Abstract

The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed to assess whether successful awake proning of patients with COVID-19, requiring respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) on a respiratory high-dependency unit (HDU), is associated with improved outcomes. HDU care included awake proning by respiratory physiotherapists. Of 565 patients admitted with COVID-19, 71 (12.6%) were managed on the respiratory HDU, with 48 of these (67.6%) requiring respiratory support. Patients managed with CPAP alone 22/48 (45.8%) were significantly less likely to die than patients who required transfer onto HFNO 26/48 (54.2%): CPAP mortality 36.4%; HFNO mortality 69.2%, (p=0.023); however, multivariate analysis demonstrated that increasing age and the inability to awake prone were the only independent predictors of COVID-19 mortality. The mortality of patients with COVID-19 requiring respiratory support is considerable. Data from our cohort managed on HDU show that CPAP and awake proning are possible in a selected population of COVID-19, and may be useful. Further prospective studies are required.

DOI: 10.1136/bmjresp-2020-000678
PubMed: 32928787
PubMed Central: PMC7490910

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Hardinge, Maxine" sort="Hardinge, Maxine" uniqKey="Hardinge M" first="Maxine" last="Hardinge">Maxine Hardinge</name>
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<author><name sortKey="Hoyles, Rachel K" sort="Hoyles, Rachel K" uniqKey="Hoyles R" first="Rachel K" last="Hoyles">Rachel K. Hoyles</name>
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<author><name sortKey="Saunders, Peter" sort="Saunders, Peter" uniqKey="Saunders P" first="Peter" last="Saunders">Peter Saunders</name>
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<author><name sortKey="Sykes, Anny" sort="Sykes, Anny" uniqKey="Sykes A" first="Anny" last="Sykes">Anny Sykes</name>
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<author><name sortKey="Wrightson, John M" sort="Wrightson, John M" uniqKey="Wrightson J" first="John M" last="Wrightson">John M. Wrightson</name>
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<author><name sortKey="Moore, Alastair" sort="Moore, Alastair" uniqKey="Moore A" first="Alastair" last="Moore">Alastair Moore</name>
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<author><name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name>
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</placeName>
<orgName type="university">Université d'Oxford</orgName>
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<author><name sortKey="Fraser, Emily" sort="Fraser, Emily" uniqKey="Fraser E" first="Emily" last="Fraser">Emily Fraser</name>
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<author><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name>
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<author><name sortKey="Talbot, Nicholas P" sort="Talbot, Nicholas P" uniqKey="Talbot N" first="Nicholas P" last="Talbot">Nicholas P. Talbot</name>
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<author><name sortKey="Bafadhel, Mona" sort="Bafadhel, Mona" uniqKey="Bafadhel M" first="Mona" last="Bafadhel">Mona Bafadhel</name>
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<affiliation wicri:level="4"><nlm:affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
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<author><name sortKey="Petousi, Nayia" sort="Petousi, Nayia" uniqKey="Petousi N" first="Nayia" last="Petousi">Nayia Petousi</name>
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<author><name sortKey="Rahman, Najib M" sort="Rahman, Najib M" uniqKey="Rahman N" first="Najib M" last="Rahman">Najib M. Rahman</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.</title>
<author><name sortKey="Hallifax, Rob J" sort="Hallifax, Rob J" uniqKey="Hallifax R" first="Rob J" last="Hallifax">Rob J. Hallifax</name>
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<country wicri:rule="url">Royaume-Uni</country>
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<placeName><settlement type="city">Oxford</settlement>
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<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Porter, Benedict Ml" sort="Porter, Benedict Ml" uniqKey="Porter B" first="Benedict Ml" last="Porter">Benedict Ml Porter</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elder, Patrick Jd" sort="Elder, Patrick Jd" uniqKey="Elder P" first="Patrick Jd" last="Elder">Patrick Jd Elder</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, Sarah B" sort="Evans, Sarah B" uniqKey="Evans S" first="Sarah B" last="Evans">Sarah B. Evans</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Hynes, Gareth" sort="Hynes, Gareth" uniqKey="Hynes G" first="Gareth" last="Hynes">Gareth Hynes</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lardner, Rachel" sort="Lardner, Rachel" uniqKey="Lardner R" first="Rachel" last="Lardner">Rachel Lardner</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Archer, Kirsty" sort="Archer, Kirsty" uniqKey="Archer K" first="Kirsty" last="Archer">Kirsty Archer</name>
<affiliation wicri:level="3"><nlm:affiliation>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bettinson, Henry V" sort="Bettinson, Henry V" uniqKey="Bettinson H" first="Henry V" last="Bettinson">Henry V. Bettinson</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nickol, Annabel H" sort="Nickol, Annabel H" uniqKey="Nickol A" first="Annabel H" last="Nickol">Annabel H. Nickol</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flight, William G" sort="Flight, William G" uniqKey="Flight W" first="William G" last="Flight">William G. Flight</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chapman, Stephen J" sort="Chapman, Stephen J" uniqKey="Chapman S" first="Stephen J" last="Chapman">Stephen J. Chapman</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hardinge, Maxine" sort="Hardinge, Maxine" uniqKey="Hardinge M" first="Maxine" last="Hardinge">Maxine Hardinge</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoyles, Rachel K" sort="Hoyles, Rachel K" uniqKey="Hoyles R" first="Rachel K" last="Hoyles">Rachel K. Hoyles</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saunders, Peter" sort="Saunders, Peter" uniqKey="Saunders P" first="Peter" last="Saunders">Peter Saunders</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sykes, Anny" sort="Sykes, Anny" uniqKey="Sykes A" first="Anny" last="Sykes">Anny Sykes</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wrightson, John M" sort="Wrightson, John M" uniqKey="Wrightson J" first="John M" last="Wrightson">John M. Wrightson</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moore, Alastair" sort="Moore, Alastair" uniqKey="Moore A" first="Alastair" last="Moore">Alastair Moore</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Fraser, Emily" sort="Fraser, Emily" uniqKey="Fraser E" first="Emily" last="Fraser">Emily Fraser</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name>
<affiliation wicri:level="4"><nlm:affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Talbot, Nicholas P" sort="Talbot, Nicholas P" uniqKey="Talbot N" first="Nicholas P" last="Talbot">Nicholas P. Talbot</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Bafadhel, Mona" sort="Bafadhel, Mona" uniqKey="Bafadhel M" first="Mona" last="Bafadhel">Mona Bafadhel</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Petousi, Nayia" sort="Petousi, Nayia" uniqKey="Petousi N" first="Nayia" last="Petousi">Nayia Petousi</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Rahman, Najib M" sort="Rahman, Najib M" uniqKey="Rahman N" first="Najib M" last="Rahman">Najib M. Rahman</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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</analytic>
<series><title level="j">BMJ open respiratory research</title>
<idno type="eISSN">2052-4439</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Continuous Positive Airway Pressure (methods)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Disease Progression (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Noninvasive Ventilation (methods)</term>
<term>Odds Ratio (MeSH)</term>
<term>Oxygen Inhalation Therapy (methods)</term>
<term>Pandemics (MeSH)</term>
<term>Patient Positioning (methods)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Prone Position (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>United Kingdom (MeSH)</term>
<term>Wakefulness (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Décubitus ventral (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Mâle (MeSH)</term>
<term>Odds ratio (MeSH)</term>
<term>Oxygénothérapie (méthodes)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Positionnement du patient (méthodes)</term>
<term>Royaume-Uni (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Ventilation en pression positive continue (méthodes)</term>
<term>Ventilation non effractive (méthodes)</term>
<term>Vigilance (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
<term>Évolution de la maladie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United Kingdom</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Continuous Positive Airway Pressure</term>
<term>Noninvasive Ventilation</term>
<term>Oxygen Inhalation Therapy</term>
<term>Patient Positioning</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Oxygénothérapie</term>
<term>Positionnement du patient</term>
<term>Ventilation en pression positive continue</term>
<term>Ventilation non effractive</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
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<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Betacoronavirus</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Pandemics</term>
<term>Prone Position</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
<term>Wakefulness</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Décubitus ventral</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Pandémies</term>
<term>Royaume-Uni</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vigilance</term>
<term>Études rétrospectives</term>
<term>Évolution de la maladie</term>
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<front><div type="abstract" xml:lang="en">The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed to assess whether successful awake proning of patients with COVID-19, requiring respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) on a respiratory high-dependency unit (HDU), is associated with improved outcomes. HDU care included awake proning by respiratory physiotherapists. Of 565 patients admitted with COVID-19, 71 (12.6%) were managed on the respiratory HDU, with 48 of these (67.6%) requiring respiratory support. Patients managed with CPAP alone 22/48 (45.8%) were significantly less likely to die than patients who required transfer onto HFNO 26/48 (54.2%): CPAP mortality 36.4%; HFNO mortality 69.2%, (p=0.023); however, multivariate analysis demonstrated that increasing age and the inability to awake prone were the only independent predictors of COVID-19 mortality. The mortality of patients with COVID-19 requiring respiratory support is considerable. Data from our cohort managed on HDU show that CPAP and awake proning are possible in a selected population of COVID-19, and may be useful. Further prospective studies are required.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32928787</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2052-4439</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>BMJ open respiratory research</Title>
<ISOAbbreviation>BMJ Open Respir Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">e000678</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjresp-2020-000678</ELocationID>
<Abstract><AbstractText>The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed to assess whether successful awake proning of patients with COVID-19, requiring respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) on a respiratory high-dependency unit (HDU), is associated with improved outcomes. HDU care included awake proning by respiratory physiotherapists. Of 565 patients admitted with COVID-19, 71 (12.6%) were managed on the respiratory HDU, with 48 of these (67.6%) requiring respiratory support. Patients managed with CPAP alone 22/48 (45.8%) were significantly less likely to die than patients who required transfer onto HFNO 26/48 (54.2%): CPAP mortality 36.4%; HFNO mortality 69.2%, (p=0.023); however, multivariate analysis demonstrated that increasing age and the inability to awake prone were the only independent predictors of COVID-19 mortality. The mortality of patients with COVID-19 requiring respiratory support is considerable. Data from our cohort managed on HDU show that CPAP and awake proning are possible in a selected population of COVID-19, and may be useful. Further prospective studies are required.</AbstractText>
<CopyrightInformation>© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hallifax</LastName>
<ForeName>Rob J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK Rob.Hallifax@ouh.nhs.uk.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Porter</LastName>
<ForeName>Benedict Ml</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Elder</LastName>
<ForeName>Patrick Jd</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Evans</LastName>
<ForeName>Sarah B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Turnbull</LastName>
<ForeName>Chris D</ForeName>
<Initials>CD</Initials>
<Identifier Source="ORCID">0000-0001-8942-5424</Identifier>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hynes</LastName>
<ForeName>Gareth</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lardner</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Archer</LastName>
<ForeName>Kirsty</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Therapies Clinical Service Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bettinson</LastName>
<ForeName>Henry V</ForeName>
<Initials>HV</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nickol</LastName>
<ForeName>Annabel H</ForeName>
<Initials>AH</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Flight</LastName>
<ForeName>William G</ForeName>
<Initials>WG</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>Stephen J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hardinge</LastName>
<ForeName>Maxine</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoyles</LastName>
<ForeName>Rachel K</ForeName>
<Initials>RK</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saunders</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sykes</LastName>
<ForeName>Anny</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wrightson</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moore</LastName>
<ForeName>Alastair</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ho</LastName>
<ForeName>Ling-Pei</ForeName>
<Initials>LP</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fraser</LastName>
<ForeName>Emily</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pavord</LastName>
<ForeName>Ian D</ForeName>
<Initials>ID</Initials>
<AffiliationInfo><Affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Talbot</LastName>
<ForeName>Nicholas P</ForeName>
<Initials>NP</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bafadhel</LastName>
<ForeName>Mona</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-9993-2478</Identifier>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petousi</LastName>
<ForeName>Nayia</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rahman</LastName>
<ForeName>Najib M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Oxford Respiratory Group</CollectiveName>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMJ Open Respir Res</MedlineTA>
<NlmUniqueID>101638061</NlmUniqueID>
<ISSNLinking>2052-4439</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045422" MajorTopicYN="N">Continuous Positive Airway Pressure</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063087" MajorTopicYN="N">Noninvasive Ventilation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010102" MajorTopicYN="N">Oxygen Inhalation Therapy</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056888" MajorTopicYN="N">Patient Positioning</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016684" MajorTopicYN="Y">Prone Position</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006113" MajorTopicYN="N" Type="Geographic">United Kingdom</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014851" MajorTopicYN="N">Wakefulness</DescriptorName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">non invasive ventilation</Keyword>
<Keyword MajorTopicYN="Y">respiratory infection</Keyword>
<Keyword MajorTopicYN="Y">viral infection</Keyword>
</KeywordList>
<CoiStatement>Competing interests: None declared.</CoiStatement>
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<name sortKey="Hardinge, Maxine" sort="Hardinge, Maxine" uniqKey="Hardinge M" first="Maxine" last="Hardinge">Maxine Hardinge</name>
<name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name>
<name sortKey="Ho, Ling Pei" sort="Ho, Ling Pei" uniqKey="Ho L" first="Ling-Pei" last="Ho">Ling-Pei Ho</name>
<name sortKey="Hoyles, Rachel K" sort="Hoyles, Rachel K" uniqKey="Hoyles R" first="Rachel K" last="Hoyles">Rachel K. Hoyles</name>
<name sortKey="Hynes, Gareth" sort="Hynes, Gareth" uniqKey="Hynes G" first="Gareth" last="Hynes">Gareth Hynes</name>
<name sortKey="Lardner, Rachel" sort="Lardner, Rachel" uniqKey="Lardner R" first="Rachel" last="Lardner">Rachel Lardner</name>
<name sortKey="Lardner, Rachel" sort="Lardner, Rachel" uniqKey="Lardner R" first="Rachel" last="Lardner">Rachel Lardner</name>
<name sortKey="Moore, Alastair" sort="Moore, Alastair" uniqKey="Moore A" first="Alastair" last="Moore">Alastair Moore</name>
<name sortKey="Nickol, Annabel H" sort="Nickol, Annabel H" uniqKey="Nickol A" first="Annabel H" last="Nickol">Annabel H. Nickol</name>
<name sortKey="Pavord, Ian D" sort="Pavord, Ian D" uniqKey="Pavord I" first="Ian D" last="Pavord">Ian D. Pavord</name>
<name sortKey="Petousi, Nayia" sort="Petousi, Nayia" uniqKey="Petousi N" first="Nayia" last="Petousi">Nayia Petousi</name>
<name sortKey="Petousi, Nayia" sort="Petousi, Nayia" uniqKey="Petousi N" first="Nayia" last="Petousi">Nayia Petousi</name>
<name sortKey="Porter, Benedict Ml" sort="Porter, Benedict Ml" uniqKey="Porter B" first="Benedict Ml" last="Porter">Benedict Ml Porter</name>
<name sortKey="Rahman, Najib M" sort="Rahman, Najib M" uniqKey="Rahman N" first="Najib M" last="Rahman">Najib M. Rahman</name>
<name sortKey="Rahman, Najib M" sort="Rahman, Najib M" uniqKey="Rahman N" first="Najib M" last="Rahman">Najib M. Rahman</name>
<name sortKey="Saunders, Peter" sort="Saunders, Peter" uniqKey="Saunders P" first="Peter" last="Saunders">Peter Saunders</name>
<name sortKey="Sykes, Anny" sort="Sykes, Anny" uniqKey="Sykes A" first="Anny" last="Sykes">Anny Sykes</name>
<name sortKey="Talbot, Nicholas P" sort="Talbot, Nicholas P" uniqKey="Talbot N" first="Nicholas P" last="Talbot">Nicholas P. Talbot</name>
<name sortKey="Talbot, Nicholas P" sort="Talbot, Nicholas P" uniqKey="Talbot N" first="Nicholas P" last="Talbot">Nicholas P. Talbot</name>
<name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name>
<name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name>
<name sortKey="Wrightson, John M" sort="Wrightson, John M" uniqKey="Wrightson J" first="John M" last="Wrightson">John M. Wrightson</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000194 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32928787
   |texte=   Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32928787" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.

Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience.

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